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We must keep the fact in mind that the overall success somewhat depends on genetics

Free Radic Biol Med 22 : 11151126

Therefore, some of these protein antioxidant systems, together will glutathione, may contribute thiols to reduce the effective concentration of AX within the cell and both, the system involved and the ratio of conversion may depend on the subcellular compartment where the reaction occurs

The pathogenic processes involved are multifactorial, encompassing direct impacts on the host and cooperative interactions with indigenous commensal microbiota that can lead to immune dysregulation