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Its extended half-life also supports experimental designs requiring sustained receptor engagement over longer observation periods
doi: 10.3390/ijms241612553 42
Nov 19 2014;33(1):33
As a result, GLP-1 medications are contraindicated in patients with a personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
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The protective effects of liraglutide against A-induced neurotoxicity in neuroblastoma cells are attributed to the activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, as evidenced by the increased phosphorylation of Akt and the altered expression of the apoptosis-related proteins Bcl-2/Bax, and cytochrome c [49]
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