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Cytotoxic CD8+ T lymphocytes (CTL), together with other immune cells and mechanisms, target infected hepatocytes, leading to apoptosis and necrosis, which drive liver inflammation and damage

Devlin 2 , Eric Sheu 1 1 Surgery, Brigham and Women's Hospital, Boston, Massachusetts, United States, 2 Harvard Medical School, Boston, Massachusetts, United States, 3 Affinivax, Cambridge, Massachusetts, United States 1

We have also seen this pattern directly in major trials

There is, however, evidence to support considering closer follow-up when initiating a GLP-1 RA, particularly if rapid improvement in glycemic control is anticipated, following a baseline dilated fundus examination performed around the time of therapy initiation