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Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland Abstract Reactive oxygen and nitrogen species can be generated endogenously (by mitochondria, peroxisomes, and phagocytic cells) and exogenously (by pollutions, UV exposure, xenobiotic compounds, and cigarette smoke)

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Many of its effects are mediated through a hormone called IGF-1 (Insulin-Like Growth Factor 1) , which is primarily produced in the liver in response to GH signaling