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The high-resolution structures revealed that cagrilintide adopts an amylin-like binding mode, characterized by a bypass motif

BiofactorsSchmelzerC.LorenzG.RimbachG.DringF

BioMed Pharmacother (2021) 137:111382

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Notably, OG treatment shifted macrophage polarization toward an anti-inflammatory M2 phenotype and increased mitochondrial activity, facilitating adipose tissue remodeling and enhancing energy expenditure and thermogenesis