Cardiovascular effects In a PIONEER 6 cardiovascular outcomes trial (CVOT), patients with type 2 diabetes and established cardiovascular diseases used oral semaglutide (Rybelsus)
The risk increases if tirzepatide causes rapid weight loss (greater than 23 pounds per week), which can amplify hypotensive effects
Semaglutide works by imitating the effects of GLP-1, a hormone your body naturally releases after eating
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