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Serum F protein is produced across a wide variety of mammalian species [89]
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Key astrocyte-derived factors include C-X-C motif chemokine ligand (CXCL10), stromal-derived factor 1 (CXCL12), Fas ligand (FasL/CD95L), TNF superfamily member 10, TNF-related apoptosis-inducing ligand 2 (TRAIL), high mobility group B1 protein (HMGB1), A and lipocalin-2 (LCN-2)
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Conversely, a cohort study using standard dietetic advice to produce intentional weight loss in older adults with T2D demonstrated that every 1 kg of weight loss was an associated 34 months survival prolongation [64], and a meta-analysis of RCTs assessing the impact of intentional weight loss on mortality found a 15%, although the mean age of participants was 52 years [65]
