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Thats because a 500mg dose of powder amounts to 439mg of berberine, which doesnt exactly align with a clinical dose

This thermal energy gives your skins fibroblasts an extra signal to ramp up collagen and elastin production, making it especially effective for improving the color, depth, and texture of stubborn stretch marks

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Ross AE, Tang MY, Gemeinhart RA: Effects of molecular weight and loading on matrix metalloproteinase-2 mediated release from poly(ethylene glycol) diacrylate hydrogels