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Current strategies focus not only on targeting the BBB endothelium but also on the effective transport of specific compounds across it and the subsequent targeted drug release at appropriate targets in the brain ( Strategies under study to cross the BBB include viral vectors (257) as gene therapy delivery, enhancement of brain permeability (258), delivery through the pathologic permeable BBB, intranasal drug administration to bypass the BBB (259), nanoparticles (NPs) to actively target the brain, or delivery through active BBB transporters (260), brain cancer (261), and even stroke (262)

Complete blood count (CBC): Establishes red and white cell indices and platelet counts

Commonly discussed options include injectable, oral, and topical forms

May require administration by a healthcare professional

Bosnyak S, Welungoda IK, Hallberg A, Alterman M, Widdop RE, Jones ES

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