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A transmembrane intracellular estrogen receptor mediates rapid cell signaling

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The extracellular domain of DPP-4, which harbors its catalytic site, often gets released from the membrane and circulates in plasma

However, our findings contrast with those of other clinical studies, in which acute administration of metformin was reported to have little effect on the insulin response to a standardised test meal in individuals with type 2 diabetes [8, 14, 24]

DDR pathway activation phosphorylates and activates p53, which subsequently induces the expression of p21 23

10.1155/2021/5542545 91 LiuN.XuH.SunQ.YuX.ChenW.WeiH.et al (2021b)