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Shortly afterwards, in October 1964, Harold Elrick and his colleagues at the University of Colorado Medical School, independently showed that oral doses of glucose produced significantly higher levels of plasma insulin than when given by intravenous injection (Elrick, Stimler, Arai)

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Explanation of these results includes optimum treatment of ASCVD patients (during the study)

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Starting with a lower dose and taking it with food can help mitigate this

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