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It is worth being direct about the state of the evidence, because DSIP is a compound where the name promises more than the literature delivers
After 56 weeks: Placebo group lost 1.2% of body weight Recommended dose (7.5/46 mg) group lost 7.8% of body weight Top dose (15/92 mg) group lost 9.8% of body weight The EQUIP trial enrolled 1,267 adults with class II and III obesity (BMI 35+)
Ethics declarations Ethical Approval and Consent to Participates This manuscript does not contain any studies with human participants or animals performed by any of the authors
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Disruptions in iron metabolism, lipid metabolism, and the collapse of cellular oxidative defense systems can accelerate the production of lipid peroxides, damaging the CNS and leading to secondary injuries in acute CNS injuries and NDDs (Ratan, 2020)
Specifically, a decline in estrogen levels, which may result from various conditions such as polycystic ovary syndrome or premature ovarian failure, as well as from natural physiological changes like menopause, appears to facilitate the onset and progression of OSAHS
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