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In clinical trials, Wegovy has shown promising results, with participants losing an average of 15% of their body weight over a 68-week period

These agents target multiple hormone pathways involved in appetite regulation, insulin secretion, energy expenditure, and hepatic metabolism

A post-hoc analysis of the four SURMOUNT trials, which included 2,999 women and 1,678 men, found that all doses of tirzepatide produced consistent body weight reductions across both sexes, but women experienced greater percentage weight loss than men

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Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors