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When to Talk With a Doctor Patients should consider speaking with a physician if they have persistent fatigue, unexplained weight changes, poor recovery, worsening brain fog, low exercise tolerance, recurrent crashes, symptoms after rapid weight loss, or interest in NAD+ or MOTS-c therapy

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A regular dose will also elicit results similar to loading after about four weeks of use (10)

However, knowledge in this field is emerging rapidly, with numerous publications appearing frequently