These findings are also interesting from an IGF-1R targeting point of view because pharmacological modulations leading to an excess of MDM2 could be a manner to cause a selective IGF-1 inhibition and apoptosis in cancer cells
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Immediate medical attention is required if taste changes are accompanied by: Severe, persistent vomiting preventing adequate fluid intake Signs of dehydration (dark urine, dizziness, decreased urination) Severe abdominal pain, particularly if persistent or worsening Symptoms of pancreatitis (severe upper abdominal pain radiating to the back, nausea, vomiting) Right upper quadrant pain, fever, or yellowing of skin/eyes (possible gallbladder disease) Symptoms of hypoglycemia (if also taking insulin or sulfonylureas): shakiness, sweating, confusion, irritability These symptoms may indicate serious adverse effects requiring urgent evaluation, including pancreatitis, gallbladder disease, gastroparesis, or severe dehydration
Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation
McCarthy MS, Elshaw EB, Szekely BM, Raju D
