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The muscle circadian rhythm promotes neutral lipid storage by brain and muscle arnt-like 1-dependent activation of DGAT2, while REV-ERB suppresses key target genes to downregulate lipid degradation and protein turnover [112]

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A contrasting pattern was detected for the gene expression of cytochrome c oxidase subunit 4I1 (COX4I1), with stable levels in CON and a downregulation in CAR due to LPS injection

This drives greater metabolic health