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VPA is used to treat psychiatric disorders and as such there is an association with accidental or deliberate overdose, the incidence of which is increasing [135, 136]

Injecting too superficially, failing to rotate sites adequately, or not allowing alcohol to dry completely before injection all contribute to local reactions

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Its cell-penetrating properties allow it to enter cells without transfection or vector delivery, where it directly engages the p53 TAD2 domain to disrupt the FOXO4-p53 complex