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Nrf2 in cancers: a double-edged sword

Therefore, future research is needed to identify new therapeutic targets

We look at what the dose-dependent timing says about when risk peaks during titration (Section 5.1), the mechanism that makes the link biologically plausible (Section 5.2), what the treatment response tells us about management (Section 5.3), where the case fits against existing pharmacovigilance data (Section 5.4), and what it means at the bedside (Section 5.5)

Khajuria A and Houston DS (2000)

You may notice appetite suppression within weeks, but significant weight loss typically occurs over several months with gradual dose titration

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