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15 A 2023 update confirmed that loneliness is as dangerous as smoking or obesity

Under normal physiological conditions, activation of the Keap1-NRF2 signaling pathway promotes the activation of System Xc - and the expression of GPX4 and accelerates cysteine glutamate transport, thereby clearing accumulated lipid peroxidation and inhibiting ferroptosis (86)

Nat Commun 13 , 1789 (2022)

MTHF = methylenetetrahydrofolate

doi: 10.1016/0895-4356(94)90117-1

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