Do not discontinue Ozempic abruptly without medical advice
The LEADER trial demonstrated cardiovascular benefits with liraglutide while other large outcome studies show GLP 1 medications improve endothelial function, reduce blood pressure modestly and favorably modify inflammatory and lipid markers
Lutomski P et al
Chronic hyperglycemia can cause macrovascular complications such as coronary artery disease, peripheral vascular disease, and cerebrovascular disease, and microvascular complications, including retinopathy, nephropathy, and neuropathy [7]
Not all patients achieve clinically significant weight loss, and there is currently no reliable method to predict which individuals will respond optimally
Recent studies reported that GLP-1R agonists, such as Val 8 -GLP-1(7-36), exendin-4 and liraglutide, attenuated A 1-42 -induced calcium overload by regulating intracellular calcium homeostasis in cortical or hippocampal pyramidal cells (173, 205, 206)