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While severe hypoglycemia is uncommon with tirzepatide monotherapy due to its glucose-dependent mechanism, combining it with other glucose-lowering agents or supplements increases risk

Trypsin inhibitors from various plants are known for their antiproliferative properties (427)

Preclinical studies have suggested that GLP-1 receptors may be expressed on osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells), primarily in animal models

However, critical barriers impede clinical translation

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In conclusion, the path forward lies in embracing complexity rather than simplifying it