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Zepbound and Retatrutide do share the same baseline of gastrointestinal side effects (like nausea and constipation), however, because Retatrutide targets a third hormone (glucagon), it introduces a couple of side effects not seen with Zepbound, specifically related to heart rate and skin sensitivity

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Aroda VR, Bain SC, Cariou B, Piletic M, Rose L, Axelsen M, et al