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Diabetol Metab Syndr 6:80 Maramai S, Benchekroun M, Gabr MT, Yahiaoui S (2020) Multitarget therapeutic strategies for Alzheimers disease: review on emerging target combinations

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Introduction Atherosclerosis, the underlying cause of cardiac ischemia, heart failure, heart attack, stroke, and peripheral vascular disease, is known to be one of the major causes of death and morbidity worldwide (Kim & Shim, 2019)

In a rat model of carrageenan-induced acute peripheral inflammation, liraglutide significantly reduced hypersensitivity to mechanical and cold stimuli through its anti-inflammatory effects, notably by increasing interleukin-10 (IL-10) levels and suppressing tumor necrosis factor- (TNF-) expression in inflamed tissue [29] (Fig

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