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Clozapine N-oxide (CNO) activation of Gq receptors expressed exclusively in GCG + neurons leads to a decrease in food intake

In this context, the activity of preproglucagon-expressing neurons in the NTS is stimulated by afferent vagal inputs that relay satiety signals from the periphery to the brain, such as gastric distention, the induction of peripheral GLP-1Rs or the release of the satiety-associated hormones cholecystokinin and leptin

Obvious vacuoles, very small amounts of sperm, a small number of early spermatogenic cells, extremely disordered cell arrangement, reduced cell layer number, the disappearance of cell polarity and a reduced Johnsen score were observed