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In the extrinsic pathway, IFN- secreted by cutaneous lymphocyte-associated antigen-positive (CLA + ) T cells upregulates Fas expression on keratinocytes (Trautmann et al., 2000), rendering them sensitive to FasL-mediated signaling

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doi: 10.1371/journal.pone.0048643 109 ZhangYMengFSunXSunXHuMCuiPet al

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In healthy obese patients, moderate improvements were seen when L-carnitine supplementation was combined with moderate aerobic training and a calorie-controlled diet