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IGF-1 LR3 introduces two modifications: R3 substitution : replacement of glutamic acid at position 3 (Glu3) by arginine (Arg3)

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Ligand engagement promotes receptor autophosphorylation on intracellular tyrosine residues and recruitment of adaptor proteins such as IRS and Shc

Add soluble fiber like oats or psyllium, which absorbs water and can firm up stools

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