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In some embodiments, an otic high viscosity formulation or device is administered as monotherapy for treatment of an otic disease or condition described herein

This route achieves near 100% bioavailability and allows for relatively painless self-administration with minimal technical skill required

Rats were pretreated with icv scopolamine (70 nmol in 2 aCSF) 20 min prior to training followed 15 minutes later by an ip injection of dihexa in DMSO ( 1 %) at .05mg/kg, .25mg/kg, or .50mg/kg

Among them, several genes seemed to be involved in mitochondrial metabolism and oxidative stress, as e.g., SLC25A39