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Compared with the metformin plus sulfonylurea combination, the lowest risk for all three investigated endpoints, namely MACE, severe hypoglycemia, and all cause-mortality, was seen for people treated with metformin in combination with SGLT2is and GLP-1RAs (HR, 0.53 [95% CI, 0.350.80] for MACE

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Eloralintide mimics the actions of amylin, a hormone that slows gastric emptying and suppresses hunger

Due to the inherent uncertainty regarding the causality of SZ, potential confounding variables related to exposure-associated IVs were not adequately controlled for, and we employed a filtration process to eliminate and exclude confounding variables specifically linked to SZ utilizing "phenoscanner" R package [30]