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It has been widely studied for its ability to promote relaxation, reduce stress, and improve focusall without the sedative effects associated with other calming agents

Second, GPER has complex and inconsistent functions in different diseases, with varying roles in different cancers and notable sex-specific differences

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This disruption triggers neuroinflammation, with the release of pro-inflammatory cytokines and reactive oxygen species, leading to further brain damage and contributing to the severe neurological symptoms characteristic of the disease, often resulting in death in the absence of treatment 14,15,16,17