POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation
The fusion peptide demonstrated sleep-promoting effects, influenced neurotransmitter levels (5-HT, glutamate, dopamine, melatonin), and confirmed that the Tat cell-penetrating sequence was the more effective BBB carrier of two tested candidates establishing DSIP as a validated active scaffold for BBB-crossing fusion peptide sleep research and supporting the development of next-generation DSIP-based neuromodulatory tools
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Medications include alpha-blockers and drugs that inhibit dihydrotestosterone production