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Sodium Imbalance in Patients with Acquired HO and Central Diabetes Insipidus: Patients with acquired HO and concomitant central diabetes insipidus (DI)/arginine vasopressin (AVP) deficiency reported hyponatremia in 6% of IMCIVREE-treated patients and 2% of placebo-treated patients and hypernatremia in 5% of IMCIVREE-treated patients and 4% of placebo-treated patients

Management options may include dose adjustment, additional support for managing gastrointestinal side effects, referral to diabetes psychology services, or consideration of alternative diabetes medications if symptoms are genuinely medication-related and problematic

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The makers of the name brand drugs, Novo Nordisk and Eli Lilly, have sent cease and desist letters and filed lawsuits against providers