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Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Engen et al., 2020) (Figure 10)

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Healthcare professionals should exercise caution when administering methylene blue to patients on serotonergic drugs, given the risk of serotonin syndrome

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[DOI] [PubMed] [Google Scholar] Evan PS, Sonal C, Mahaboob KR