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A single or short-term dose of approximately 50,000 IU can provoke toxic conditions such as vomiting, increased cerebrospinal fluid pressure, blurred vision, and impaired muscle coordination (Eldredge et al., 2022)

10.1111/dom.13172 Diabetes Obes

Effects of long-term whole-body cold exposures on plasma concentrations of ACTH, beta-endorphin, cortisol, catecholamines and cytokines in healthy females

Recently, the expression of the GLP-1 receptor has been reported in the knee joint of rat cartilage 35 and in chondrocytes from mouse tracheal cartilage 36 , but has never been described in OA patients or in mouse articular cartilage and synovial membrane

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As always, patients should be informed of the products limitations , including its lack of FDA approval and the limited clinical trial data available