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To account for the induction of ALT in the breast cancer cells (21NT and BT474) and non-induction in normal cells (IBR3 and HMEC), it is known that histone H1 is expressed at higher physiological levels in normal tissues and lower levels in breast cancer cells (Scaffidi 2016)
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(Supplementary Table S1
The American Joint Replacement Registry 2022 Annual Report indicates the cumulative procedural volume for hip and knee arthroplasty grew by 14% in 2021, or 305,645 additional cases
Failing to sanitize stoppers
Small molecule inhibitors as tools to scan for active pathways do not conclusively rule out the participation of a signaling mediator if a negative result is obtained (i.e., no inhibition/augmentation of a toxic endpoint)
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