Key limitations in the study included (severe) lack of diversity and insufficient power to assess clinical outcomes
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In addition to well-demarcated tumor appearance, cytological atypia (mild nuclear pleomorphism, increased nuclear-to-cytoplasmic ratio) and extensive depletion of reticulin trabecular framework, also reported previously in GAN DIO-NASH-HCC mice 20 , tumors displayed abnormal glutamine synthetase staining
However, high doses of glutamine supplementation in certain contexts, particularly in patients with gastrointestinal cancers, have raised questions about the theoretical risk of fueling cancer growth
