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Aggregation is dangerous for two reasons

It is advisable to run appropriate controls (vehicle, doseresponse) to exclude non-specific effects in in vitro systems

Final Action: After consideration of public comments, we are finalizing, effective January 1, 2026, our proposal to supplant the existing affirmation requirement with the proposed attestation statement at new 180.50(a)(3)(iii), with a modification to add the following phrase to the beginning of the attestation: To the best of its knowledge and belief,

The prednisolone crosses the placenta and it is excreted into breast milk in small amounts

Body composition measurements via DEXA scan or bioimpedance scale every 4-8 weeks