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NOTE: If you develop gastroparesis, a frequent side effect of high doses of this medication, seek immediate medical attention

Indeed, P4HA1 catalyzes the hydroxylation of proline residues into 4-hydroxyproline at the Y position in the Glycine-XY motif of collagen chains stabilizing collagen triple helix [23, 63]

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Among the tissues and organs crucial in regulating glucose and lipid metabolism, pancreas, brain, and adipocytes express GIP receptors (GIPRs), while pancreas, brain, and gastrointestinal tract are rich in GLP-1 receptors (GLP-1Rs) ( The hormonal binding at the extracellular domain is communicated to the intracellular receptor side, leading to G protein engagement and activation ( 2.3 Interaction of GIP and GLP-1 in the incretin effect Studies in rodents ( Figure 1 Section A]

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