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Unlike classical protonophores such as FCCP and 2,4-dinitrophenol which cause rapid and complete collapse of the mitochondrial membrane potential, leading to full depolarization, severe off-target effects including plasma membrane disruption and dose-dependent cytotoxicity (55), fatty acid anion transporters such as SR4 may provide greater mitochondrial specificity and safety through gradual, physiologically controlled depolarization

( d, j, l-m ) % relative survival normalized to vehicle

Cell 2012

Draw 20-60 units

PMCID: PMC4953733

When the woman left the property on 21 February, her departure confirmed that El Mencho had remained behind