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Specifically, it is hard to elevate glutathione levels beyond homeostasis inside cells

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42 This circulation not only supplies anabolic factorssuch as transforming growth factor-beta (TGF-) and insulin-like growth factor-1 (IGF-1)but also aids in removing catabolic cytokines (e.g., interleukin-1, tumor necrosis factor-alpha) that would otherwise upregulate matrix metalloproteinases (MMPs) and degrade the nascent cartilage matrix

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Heavy drinking can suppress the immune system and increase the risk of sickness