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Given that the Wnt pathway shows many complex, negative and positive feedback loops interacting with redox systems and NK-B signaling, manipulations of Wnt signaling and -catenin (despite being a hub and master switch) appear to be very challenging

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The highly conserved mechanistic target of rapamycin (mTOR) regulates protein synthesis, metabolism and growth

doi: 10.1186/s12937-020-00604-1 76