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The severity of colon mucosal damage was evaluated using the colonic mucosal damage index (CMDI) following the criteria outlined by 2.6 H&E and AB-PAS staining Paraffin-embedded colonic tissue blocks were cut into 4-m-thick sections for H&E staining (Table 2

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5-amino-1mq distribution 5-amino-1mq shows a different distribution profile: Moderate distribution to peripheral tissues Lower volume of distribution compared to SLU-PP-332 Limited penetration of the blood-brain barrier The distribution pattern of 5-amino-1mq may make it more suitable for certain therapeutic applications while limiting its use in others

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The December 2024 FDA advisory committee cited insufficient safety data for the injectable route as one reason for declining to approve compounding