The Role of Genetic Testing in Predicting GLP-1 Side Effects The PlexusDx Precision Peptide Genetic Test ($99 add-on after your first month) analyzes GLP1R (rs6923761), GIPR, FTO, and MC4R variants that relate to GLP-1 and related signaling pathways
It is approved by the Food and Drug Administration (FDA) for weight loss and long-term weight management in adults and adolescents 12 years and older with obesity, as well as adults who are overweight and have at least one weight-related health condition, such as high cholesterol or Type 2 diabetes
[10] [11] The risk with metformin alone is lower but still requires monitoring P-glycoprotein (P-gp) and CYP3A4 substrates : Berberine may inhibit these important drug transporters and enzymes, potentially affecting levels of medicines with a narrow therapeutic index, including: Immunosuppressants (ciclosporin, tacrolimus) Direct oral anticoagulants (DOACs) and warfarin Digoxin Some statins (particularly simvastatin, atorvastatin) Anticoagulants and antiplatelet drugs : Theoretical increased bleeding risk Antihypertensive medications : Possible additive blood pressure-lowering effects When to seek medical advice : Persistent or severe gastrointestinal symptoms Signs of hypoglycaemia (shakiness, sweating, confusion, rapid heartbeat) Unexplained fatigue or jaundice (yellowing of skin or eyes) Any unusual symptoms after starting berberine Seek urgent medical help for severe hypoglycaemia (confusion, seizures, loss of consciousness) or signs of severe allergic reaction (difficulty breathing, swelling of face/throat)
This feedback has led us to explore alternatives to the injectable medications we compound here at Potters House Apothecary
One of the innovative options we offer is compounded Semaglutide GLP-1, a customized formulation of the medication Semaglutide GLP-1, which has shown promising results in weight loss management
Cyanocobalamin works but requires more metabolic conversion and releases trace cyanide (clinically insignificant at normal doses, but unnecessary when better forms exist)
