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One paper ( via the VEGF/ERK signaling pathway after traumatic brain injury, implying that it might improve prognosis following HIBD by promoting endogenous neurogenesis

Clinical trial studies regarding the effect of -LA supplementation on migraine were limited, and the existing studies prescribed different therapeutic doses without examining the serum level of -LA

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Although preliminary findings suggest potential benefit in reducing autoantibodies or improving metabolic markers, these results are primarily drawn from small-scale or uncontrolled studies and lack replication in high-quality RCTs.In summary, while the biological rationale for supplement use in HT is compelling, robust clinical evidence remains limited

PMC 2657499