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MOTS-c treatment enabled 25% of the young C57BL/6J mice to enter the final running stage (highest speed) on a normal diet, but none on a HFD (Fig

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Figure 1e displays the representative histological pictures of the involved knee joints in the normal DBA/1, control and acarbose (100 mg/kg/day or 500 mg/kg/day)-treated CIA mice at day 38