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In vitro cachexia model The TNF--induced C2C12 model is a widely used muscle cell atrophy model that simulates the muscle wasting of cancer cachexia [10, 11, 25]

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Similarly, Bruno et al

At this point, the answer is more restrained: Epitalon is biologically interesting, mechanistically plausible in some settings, and supported by a limited but intriguing body of preclinical and early translational literature