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In brief, all of the mechanisms and actions that have protective efficiency on endothelium and VSMCs, can play a role in preventing vascular senescence (Figure 2)

Contraindications Do Not Use If You Have a known hypersensitivity to cobalt or any ingredient in the formulation (rare) Have Lebers disease (hereditary optic nerve atrophy) cyanocobalamin can cause rapid optic nerve atrophy Warnings and Precautions Hypokalemia (low potassium): May occur during initial treatment of severe megaloblastic anemia

Cole LK, Zhang M, Chen L, Sparagna GC, Vandel M, Xiang B, et al

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