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Chronic elevation of cortisol, leads to glutamate accumulation, excitotoxicity, and oxidative damage, underscoring its dual role in maintaining homeostasis and contributing to pathology

Other factors are the presence of a standard support dose of 100mg/kg in certain clinical practice

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In experiments with H 2 O 2 -induced rat insulinoma INS-1 cells and high-glucose-induced EA.hy926 cells, catalpol activates the Nrf2/HO-1 antioxidant signaling pathway, inhibits reactive oxygen species (ROS) production, reduces oxidative damage and -cell apoptosis, and promotes insulin synthesis and secretion (Xiao et al., 2022

TB-500, by contrast, works systemically