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Lancet Diabetes Endocrinol 2022;10:62333.ArticlePubMed 31

these agents now form an essential part of the armamentarium for appropriate cardio-metabolic risk management in T2DM [7]

Tirzepatide (Zepbound) targets two hormone pathways (GLP-1 and GIP) while semaglutide (Ozempic) targets only GLP-1

Despite their benefits, GLP-1 side effects can include gastrointestinal issues such as nausea, vomiting, diarrhea, and constipation

The medication is typically initiated at the lowest possible dose and titrated every 4 weeks based on tolerance and effect

It works by enhancing the regeneration of adenosine triphosphate (ATP)the body's primary energy currencyespecially during high-intensity activities like weightlifting, sprinting, and explosive movements