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The follicle may continue to grow under FSH stimulation, but oestradiol remains deliberately suppressed at the point when it would normally be high

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Supporting the attenuated reactivity of BDHI electrophile to-wards sulfhydryl groups in solution and a requirement for molecular recognition in BDHI labeling, we found that incubating three BDHI analogs ( 8, 10 , and 18 ) with GSH at pH 7.4 did not show any formation of a covalent adduct, whereas CA-containing compounds 11 and 20 produced more than 50% of corresponding adducts within 4 h of incubation (Figure S5A)