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The key shift we need The question is no longer: Can patients stop GLP-1s without regaining weight? It is: Which patients can taper, how slowly, with what lifestyle support, and with what monitoring? Until trials are designed to study deprescribing strategies, weight regain after abrupt withdrawal should not be framed as inevitability

Melanotan-2 may be relevant when the hypothesis intentionally includes broader melanocortin receptor biology

FDA-approved GLP-1 medications go through multiple phases of clinical trials, manufacturing oversight, and facility inspections before they reach patients

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